SUBSTITUTED PTERIDINONES, PYRIMIDINES, PYRROLOPYRIMIDINES, AND PURINES AS P90 RIBOSOMAL S6 PROTEIN KINASE-2 (RSK2) INHIBITORS: PHARMACOPHORE MODELING DATA

The RSK2 kinase is a downstream effector of the Ras/Raf/MEK/ERK pathway that is aberrantly active in a range of cancer types and has been recognized an anticancer target.The inhibition of RSK2 kinase activity would disrupt multiple pro-cancer processes; however, jumbo wind gold there are few RSK2 inhibitors.The data have been obtained for a series

Increasing irrigation efficiency is often assumed to be a means of saving water and a route to increasing irrigated agricultural production or making water available for other purposes, such as communities, industry or ecosystems.There is a growing body of literature arguing that increasing irrigation efficiency does not reduce consumptive water us

We describe two patients with a recent stroke or traumatic brain injury associated with aphasia and cognitive impairment triopods who required detention (under the Mental Health Act) as well as some form of restraint during their inpatient rehabilitation.Each of these episodes of care occurred early into the COVID-19 pandemic and we speculate that